CHEN Min,LI Changchong,ZHOU Haixia, et al. Application of voriconazole on secondary prophylaxis of invasive pulmonary aspergillosis in childhood acute leukemia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(6): 454-456.
Abstract：Objective: To investigate the role of voriconazole in secondary prophylaxis of invasive pulmonary aspergillosis in childhood acute leukemia. Methods: A retrospective study was conducted to evaluate efficiency and safety of voriconazole as secondary antifungal prophylaxis in 17 patients with acute leukemia who were hospitalized in hematology department from February 2009 to July 2012. All the patients had been previously clinical diagnosed of invasive pulmonary aspergillosis and confirmed by CT and GM test. When the phenomenon of myelosuppression came out, these patients would be given oral voriconazole per 12 hours until hematopoietic recovery. Results: Altogether there were 58 prophylaxis courses. All the patients successfully completed planned treatment without relapse IFD or significant side-effect. Conclusion: Voriconazole appears to be safe and effective for secondary prophylaxis of previous clinical proven invasive pulmonary aspergillosis in childhood acute leukemia.
