Correlation study of amniotic membrane transplantation on prevention of intrauterine adhesions after transcervical resection of adhesions
ZHANG Ling1, ZHANG Liqian1, GAO Lin2, CAO Xuequan3, ZHAO Lingping1
1.Department of Obstetrics and Gynecology, Taizhou Central Hospital, Taizhou, 318000; 2.Department of Clinical Laboratory, Taizhou Central Hospital, Taizhou, 318000; 3.Department of Pathology, Taizhou Central Hospital, Taizhou, 318000
ZHANG Ling,ZHANG Liqian,GAO Lin, et al. Correlation study of amniotic membrane transplantation on prevention of intrauterine adhesions after transcervical resection of adhesions[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(6): 433-437.
Abstract：Objective: TO observe the therapeutic effect of amniotic membrane transplantation on the prevention of intrauterine adhesions after transcervical resection of adhesions, to assess the value of amniotic membrane transplantation for intrauterine adhesions. Methods: Ninety cases of severe intrauterine adhesions patients admitted to Taizhou Central Hospital from Jan. 2013 to Jan. 2015 were selected. They were randomly divided into Group A, B and C three group (30 cases in each group). Group A: Uterine cavity type contraceptive devices were indwelled in 30 patients after transcervical resection of adhesion (TCRA); Group B: Foley saccule urinary catheters (14 Fr) were indwelled in 30 cases after TCRA; Group C: Foley sacclue urinary catheters (14 Fr) covered with fresh amniotic membrane were indwelled in the uterine cavity of 30 patients after TCRA. Patients were inspected with hysteroscopy after one and two months of operation to calculate AFS score in order to compare the clinical curative effect of three kinds of treatment method. The endometrial tissues were collected during operation and stained with HE, then, the number of the endometrial gland was counted to observe the situation of the menstrual recovery. The incidences of infection in the three groups were followed-up. Results: After two months of operation, conditions of uterine form, uterine volume and menstruation recovery were better in Group C than those in Group A and Group B (P<0.05). The endometrial glands count that was performed after HE staining was much higher in Group C than that in Group A and Group B (P<0.01). The positive rates of infection in Group C were lower than those in Group A and Group B (P<0.05). Conclusion: The effect that amniotic membrane transplantation is used to prevent intrauterine readbesion after transcervical resection of adhesions is much better than using uterine cavity type and Foley saccule urinary catheter. Amniotic membrane transplantation is a safe and effective treatment for severe intrauterine adhesions patients.
