XU Xiaoxiao,WU Feiyan,FEI Ning, et al. Study on interaction of depression, anxiety and intestinal inflammation[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(5): 348-353,358.
Abstract：Objective: To investigate the interaction and the potential mechanism of stress and intestinal inflammation. Methods: Stress model was established by eight different stress factors within 21 days, The intestinal inflammation group was established by anal enema (TNBS), stress combined with intestinal inflammation model were established by the combination of two models above. From 22 days, all rats were given behavioral tests, including forced swimming test (FST), the marble burying test, the number of fecal output and AWR test, then rats were sacrificed. The expressions of BDNF and phosphorylated cAMP in the hippocampus and frontal cortex, IL-1β, IL-6 in the ileum and colon were detected by Western Blotting. Results: The freezing time of stressed combined with intestinal infection group was significantly lower in FST, the number of marbles buried in marble burying test was also significantly lower, the number of fecal output and the score of AWR were obviously reduced when compared with merely chronic stress group or merely intestinal inflammation group. The expression of BDNF and p-CREB were reduced more significantly whether in the hippocampus or frontal cortex. The expression of IL-1β and IL-6 increased more significantly whether in the ileum or colon when compared with merely chronic stress group or merely intestinal inflammation group. Conclusion: Depression or anxiety as psychological factors, has certain interaction with intestinal inflammation. depression and anxiety emotions can increase the intestinal disorders, and the intestinal disorders can exacerbate depression or anxiety emotions also. The mechanism may be involved with enteric nervous system and central nervous system, the two system play the role by regulate the braingut peptide.
