营养干预对于非酒精性脂肪性肝病的治疗作用

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摘要目的：观察营养干预对非酒精性脂肪性肝病（NAFLD）的治疗作用。方法：56例NAFLD患者给予为期6个月的膳食营养干预，观察干预后营养素摄入量、生化指标及人体成分的变化。结果：干预后，患者每日能量摄入量及碳水化合物供能比下降，蛋白质供能比上升，差异均有统计学意义（均P＜0.01），脂肪供能比无明显改变；体质量指数（BMI）、腰臀比（WHR）、体脂肪（BFM）及内脏脂肪面积（VFA）显著下降（均P＜0.01），体蛋白（P）及骨骼肌（SMM）无明显改变；空腹血糖（FBG）、甘油三酯（TG）、胆固醇及低密度脂蛋白（LDL）明显下降（均P＜0.01），高密度脂蛋白（HDL）无明显改变。结论：合理的营养干预有助于NAFLD患者减低体质量及VFA，改善FBG及血脂谱，对NAFLD的治疗有益。

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	张蕊
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关键词 ：营养干预, 非酒精性脂肪性肝病, 人体成分

Abstract：Objective: To observe the improvement of nonalcoholic fatty liver disease (NAFLD) with nutritional intervention. Methods: Fifty-six patients with NAFLD were given diet nutritional intervention for 6 months. The changes of macronutrient intake, biochemical indexes and body composition indexes were recorded and analyzed before and after intervention. Results: Nutritional intervention led to lower intakes in daily total energy and the energy rate from carbohydrate (P<0.01) and higher intake in the energy rate from protein (P<0.01), but the energy rate from fat did not significantly change. Body mass index, waist hip ratio, body fat mass and visceral fat area were significantly decrease, while body protein and skeletal muscle mass no obviously changed after intervention. Fasting blood glucose, triglyceride, total cholesterol and low-density lipoprotein were significantly lower than the level before intervention (P<0.01), but high-density lipoprotein did not significantly change. Conclusion: Reasonable nutrition intervention can help to loss weight and visceral fat, improve serum glucose and serum lipids and thus exerts a favorable effect on nonalcoholic fatty liver disease.

Key words： nutritional intervention nonalcoholic fatty liver disease body composition

收稿日期: 2015-08-09

作者简介: 张蕊（1983-），女，天津人，营养师，硕士。

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https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2016/V46/I4/299

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