眼周肿物311例临床病理分析

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摘要目的：探讨眼周常见肿物的临床病理学类型及分布情况。方法：回顾性分析自2008-2015年间在杭州市第三人民医院病理科存档的311例眼周肿物的临床组织病理学资料。结果：在311例眼周肿物病例中，男139例（占44.69%），女172例（占55.31%），年龄1～87岁；良性病变257例（占82.64%），恶性及恶性倾向病变54例（占17.36%）。115例60岁以上患者中，恶性及恶性倾向病变43例（占37.39%）。良性病变前3位分别为寻常疣、皮内痣和脂溢性角化病；恶性及恶性倾向病变前3位分别是基底细胞癌、日光性角化病和鳞状细胞癌，平均发病年龄分别为66.85、79.33和68.83岁；恶性及恶性倾向病变主要发生在下睑（占29.63%），其次分别为内眦、眉弓、上睑和外眦。结论：眼周组织重要而精细，易于发生肿物，其中基底细胞癌是最常见的眼周恶性肿瘤，对眼周肿物应常规做病理检查。

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	芦思佳

关键词 ：眼周肿物；肿瘤, 基底细胞；病理分析

Abstract：Objective: To investigate the common clinical and pathological classifications and the distribution of periocular neoplasms. Methods: A total of 311 periocular neoplasms verified by the department of pathology at the third people’s hospital of Hangzhou from 2008 to 2015 were included in this study. Results: There were 139 male (44.69%) and 172 female (55.31%) in the 311 periocular neoplasms. The age distribution was 1 to 87 years old. Two hundred and fifty-seven (82.64%) of the lesions were benign, while 54 (17.46%) of the lesions were malignant or having malignant tendency. In 115 patients over 60 years old, 43 (37.39%) of them were malignant or having malignant tendency. The three leading benign lesions were verruca vulgaris, intradermal nevus and seborrheic keratosis; The three leading malignant lesions or lesions having malignant tendency were basal cell carcinoma, actinic keratosis and squamous cell carcinoma, the mean ages of occurrence of them were 66.85, 79.33 and 68.83 years old, respectively. The malignant lesions or lesions having malignant tendency were most commonly found on the lower eyelid (29.63%), followed by medial canthus, arcus superciliaris, upper lid and lateral canthus. Conclusion: The periocular area is important and sophisticated, it is susceptible to neoplasms. Basal cell carcinoma is the most common periocular malignant tumor. Pathological examination should be performed for periocular neoplasms to guide the diagnosis and treatment in clinics.

Key words： periocular neoplasms neoplasms, basal cell pathological analysis

收稿日期: 2015-07-09

作者简介: 芦思佳（1987-），女，辽宁鞍山人，住院医师。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2016/V46/I4/296

[1] SLUTSKY J B, JONES E C. Periocular cutaneous malignancies: a review of the literature[J]. Dermatol Surg, 2012, 38(4): 552-569.
[2] YIN V T, MERRITT H, ESMAELI B. Targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas[J]. World J Clin Cases, 2014, 2(9): 432-438.
[3] 李祯, 陆士恒, 罗媛媛, 等. 老年人眼表肿瘤46例临床分析[J]. 中华老年多器官疾病杂志, 2015, 14(1): 19-21.
[4] 安喜艳, 苏九妹. 眼睑肿物252例病理分析[J]. 中国实用眼科杂志, 2014, 32(2): 235-237.
[5] 许亚静, 龚健杨, 廖荣丰. 原发性眼眶肿瘤临床病理研究[J]. 临床眼科杂志, 2013, 21(5): 443-446.
[6] 李海燕, 袁志刚, 杨鹏霞, 等. 老年人眼肿瘤504例临床病理分析[J]. 国际眼科杂志, 2014, 14(6): 1103-1106.
[7] 魏秋彩, 李晓华, 郝远瑞. 儿童眼部肿瘤213例的病理学分类[J]. 中华眼科杂志, 2013, 49(1): 37-40.
[8] MEDINA C A, PLESEC T, SINGH A D. Optical coherence tomography imaging of ocular and periocular tumours[J]. Br J Ophthalmol, 2014, 98 Suppl 2: i40-i46.
[9] LITWIN A S, TIMLIN H, SAGILI S, et al. Acquired lacrimal sac fistula mimicking basal cell carcinoma[J]. Br J Dermatol, 2013, 168(6): 1348-1350.
[10] 顼晓琳, 李彬, 孙宪丽, 等. 2 639例眼睑肿物临床病理分析[J]. 中华眼科杂志, 2008, 44(1): 38-41.
[11] 陈荣家, 肖以钦. 2734例眼睑肿物的临床病理分析[J]. 中华眼科杂志, 2008, 44(2): 143-146.
[12] KVANNLI L, BENGER R, GAL A, et al. The method of enface frozen section in clearing periocular basal cell carcinoma and squamous cell carcinoma[J]. Orbit, 2012, 31(4): 233-237.
[13] PELOSINI L, SMITH H B, SCHOFIELD J B, et al. In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology[J]. Br J Ophthalmol, 2013, 97(7): 890-894.
[14] AVANAKI M R, HOJJATOLESLAMI A, SIRA M, et al. Investigation of basal cell carcinoma using dynamic focus optical coherence tomography[J]. Appl Opt, 2013, 52(10): 2116-2124.
[15] REEM R E, GOLDEN R P. Periocular hemangiomas and lymphangiomas[J]. Pediatr Clin North Am, 2014, 61(3): 541-553.
[16] MALHOTRA R, HUILGOL S C, HUYNH N T, et al. The Australian Mohs database, part I: periocular basal cell carcinoma experience over 7 years[J]. Ophthalmology, 2004, 111(4): 624-630.
[17] ALLALI J, D’HERMIES F, RENARD G. Basal cell carcinomas of the eyelids[J]. Ophthalmologica, 2005, 219(2): 57-71.
[18] JAYAPRAKASAM A, RENE C. A benign or malignant eyelid lump—can you tell? An unusual collision tumour highlighting the difficulty differentiating a hidrocystoma from a basal cell carcinoma[J]. BMJ Case Rep, 2012, 2012.
[19] 林孝华, 蔡剑峰, 邵笑红, 等. 色素型基底细胞癌误漏诊十例临床分析[J]. 温州医学院学报, 2005, 35(2): 165-166.
[20] ISHIOKA P, MAIA M, RODRIGUES S B, et al. Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study[J]. An Bras Dermatol, 2015, 90(3): 426-429.