ZHAI Xiaoli,LOU Shanxian,SHI Hongqi, et al. Mikulicz’s disease: a clinicopathological analysis of 51 cases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(3): 223-225.
Abstract：Objective: To explore the pathological features, differential diagnosis and prognosis of Mikulicz’s disease, and provide methods of treatment and prevention for clinicians. Methods: The clinical and pathological features of Mikulicz disease were analyzed in 51 patients and the expression of LCA, CD 20, CD 3, CD 4, CD 45RA, CD 45RO, EMA, CEA, S-100, CK, lysozyme, EBV, IgG4, HBsAg and HBcAg in Mikulicz disease were detected immunohistochemically. Results: Microscopically, the prominent features of Mikulicz disease were acinar atrophy and lymphoid tissue hyperplasia. Immunohistochemical staining showed that the lymphoid tissue was composed of a mixed population of B and T lymphocytes and about 80% of patients were IgG4 positive. Conclusion: Mikulicz disease is an autoimmune disease and mostly occurred in postmenopausal women. Postoperative recurrence may happen. Immunosuppressive agents may be helpful in treatment.
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