ZHANG Yaping,WANG Binda,LIU Chunyan, et al. Expression and clinical significance of ultra early stage biomarker blood β-actin in patient with acute cerebral infarction [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(3): 174-177.
Objective: To explore the expression level of blood β-actin and its clinical significance in ultra early stage of acute cerebral infarction. Methods: Eighty patients with acute cerebral infarction (ACI) were selected as cerebral infarction group, and they were divided into five subgroups by different periods (2 hours, 4 hours, 6 hours, 24 hours and 72 hours), 16 patients in each subgroup. Other 48 cases without cerebral infarction were selected as control group, including 16 cases of transient ischemic attack, 16 cases of cerebral hemorrhage and 16 cases of healthy contrast group. The content of blood β-actin was detected by enzyme-linked immunosorbent method and analyzed combined with clinical condition. Results: ①The content of blood β-actin in the cerebral infarction group was significantly higher than those in the control group (P<0.05). ②The diagnostic kit for ACI was determined at 2.10 ng/mL by ROC curve. It had high sensitivity and specificity. ③The level of blood β-actin in patients with acute cerebral infarction has certain correlation with the area of cerebra1 infarction as well as NIHSS scores. Conclusion: The elevated level of blood β-actin may be a practical biomarker of acute cerebral infarction in ultra early stage.
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