Transplantation of microencapsulated islets combined with renal arterial reconstruction to alleviate the early stage renal pathology in diabetic nephropathy rats
XU Ziqiang1, HE Yunqiang2, FU Hongxing3, XU Yanyan4, CAI Yong1, XIA Peng1.
1.Transplantation Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Laboratory of Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 3.School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035; 4.Department of Pharmacy, the Central Hospital of Lishui, Lishui, 323000
XU Ziqiang,HE Yunqiang,FU Hongxing, et al. Transplantation of microencapsulated islets combined with renal arterial reconstruction to alleviate the early stage renal pathology in diabetic nephropathy rats[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(3): 163-167.
Abstract：Objective: To establish rat’s model of transplantation of microencapsulated islets combined with renal arterial reconstruction and observe the curative effect of this model on the renal pathology in the early stage for the diabetic nephropathy in rats. Methods: Rat model of diabetes established by injection of a single dose of streptotocin were randomized into diabetic nephropathy (DN) group, microencapsulated islets group and combination group. After 4 weeks, 24 h proteinuria and random blood glucose level of all rats were examined, and pathological changes of the kidney and renal artery were observed under optical microscope. Results: Compared with DN group, blood glucose level and 24 h proteinuria in combination group was significantly lower. Microencapsulated islets group and combination group significantly alleviated glomerulosclerosis compared to DN group. However, there was no significant difference in the glomerulosclerosis between microencapsulated islets group and combination group. In addition, the intimal thickness of renal artery between micro-encapsulated islets group and combination group was not obvious. Conclusion: Microencapsulated islets combined with renal artery reconstruction can improve early stage renal pathology in DN rats.
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