The feasibility analysis of luteal-phase ovarian stimulation after the dominant follicle ovulated in unsynchronized multiple folliclar development patients
JIN Wumin, ZHAO Junzhao, WANG Peiyu, YU Rong, JIN Congcong
Reproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou,325000
JIN Wumin,ZHAO Junzhao,WANG Peiyu, et al. The feasibility analysis of luteal-phase ovarian stimulation after the dominant follicle ovulated in unsynchronized multiple folliclar development patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(1): 68-72.
Abstract：Objective: To explore the feasibility of luteal-phase ovarian stimulation after the dominant follicle ovulated in unsynchronized multiple folliclar development patients undergoing routine controlled ovarian hyperstimulation (CoH). Methods: From May 2012 to February 2014, 35 infertile patients undergoing in-vitro fertilization (IVF) in Reproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University were enrolled in the study. When there comes unsynchronized multiple folliclar development during the routine CoH, continue using gn until the follcle matured after the dominant follicle ovulated and serum progesterone exceeded 8 nmol/L. The highest quality embryos were extracted and cryopreserved for the next frozen embryo transfer (FET) cycles. Analyze the number of oocytes retrieved, implantation rate, clinical pregnancy rate, ongoing pregnancy rate. Results: all patients succeeded in producing oocytes except one, a total of 412 ocytes were retrieved, the average number of oocytes retrieved was 12.12±11.09, producing 167 highest quality embryos, fertilization rate was 75.40%, cleavage rate was71.12%. A total of 158 ocytes were cryopreserved for later transfer. one patient quitted cycles because of embryos’ thawing failure. A total of 34 women underwent a total of 36 FET cycles, including 33 patients who completee one FET, 3 who finished two FETs, and a total of 74 embryos were transferred.In FETs, the implantation rate and cumulative pregnancy rate were 37.83%, 52.78%, respectively. one woman was reported to have miscarried in the first trimester (5.26%). of the 19 pregnancies in the study, 10 resulted in live births and 8 were ongoing. Delivery follow-up showed 3 twin births and 7 single births,no malformations were reported in the newborns. Conclusion: Luteal-phase ovarian stimulation is feasible for producing competent oocytes/embryos in women undergoing routine controlled ovarian hyperstimulation (CoH)after the dominant follicle ovulated in unsynchronized multiple folliclar development, with optimal pregnancy outcomes in FET cycles. It’s a safety and exciting remedial measure.
