Contrastive analysis of the foxic and adverse reaction of DOF vs DOX in the treatment of advanced unresectable gastric cancer
ZHANG Yanbing1, TU Yangyang2, YE Sunzhi2, HUANG He2, WANG Feihai2, YOUTao2, ZHENG Zhiqiang2, YU Yaojun2
1.Department of General Surgery, Zhoushan Orthopedics and Traumatologic Hospital of TCM, Zhoushan, 316000; 2.Department of General Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
ZHANG Yanbing,TU Yangyang,YE SunzhI, et al. Contrastive analysis of the foxic and adverse reaction of DOF vs DOX in the treatment of advanced unresectable gastric cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(1): 60-64.
Abstract：Objective: To contrastive study the toxic and adverse events of DoF and DoX scheme in the treatment of advanced unresectable gastric cancer. Methods: Clinical data of 69 advanced gastric cancer, including 31 treated in DoF and 38 in DoX, were analyzed retrospectively in order to compare the adverse event rates and severity level in both groups. Results: Both groups underwent 3 to 8 cycles, there were 189 cycles in DoF and 233 cycles in DoX respectively. The total adverse event rates were undifferentiated at 80.0% and 81.5% when statistical analyzed by cycles (P>0.05). But the total hematologic toxicity in DoF were higher than those in DoX, especially neutropenia and thrombocytopenia which respectively were 48.7% vs 33.5% and 33.3% vs 18.0% (P<0.05). Though the total non-hematologic toxicity were similar in both groups, the stomatitis and peripheral phlebitis were higher in the former, while opposite to the hand-foot syndrome and nail toxicity, the rates respectively were 41.8% vs 15.0%, 16.4% vs 3.4%, 6.9% vs 50.6% and 4.8% vs 36.5% (P<0.05). We concluded the same results that the total hematologic toxicity and its 3/4 grade in DoF were higher than those in DoX (P<0.05), however the total adverse event rates and the total non-hematologic toxicity were similar in both groups (P>0.05), while the data were statistical analyzed by patients. Conclusion: Though the total adverse event rates are undifferentiated, the hematologic toxicity, stomatitis and peripheral phlebitis are more frequently occurred in DoF, and the hand-foot syndrome and nail toxicity are higher in DoX.
