Expression of CD147 and Survivin in renal cell carcinoma and their correlation with clinicopathologic parameters
LUO Huarong1, KE Mang2, ZHOU Tao1, XU Cheng1, BAO Weiguang3.
1.Department of Pathology,Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000; 2.Department of Urology, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000; 3.Human Tissue Bank, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000
LUO Huarong,KE Mang,ZHOU Tao, et al. Expression of CD147 and Survivin in renal cell carcinoma and their correlation with clinicopathologic parameters[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(1): 56-60.
Abstract：Objective: To investigate the expression of CD147 and Survivin in human renal cell carcinoma(RCC) and their correlation with clinicopathologic parameters. Methods: The RCC tissue microarrays containing 85 renal cell carcinoma specimens and 35 normal kidney tissue specimens were used to detect CD147 and Survivin expression by immunohistochemistry. Results: The expression rates of CD147 and Survivin were 65.7%(23/35) and 71.4% (25/35) in RCC group, respectively, significantly higher than that in control group (P<0.01).The expression of CD147 in RCC increased with the size of tumor and pathological grade (P<0.05). And the expression of Survivin in RCC increased with the pathological grade and clinical stage (P<0.05). The expression of CD147 and Survivin in RCC specimens showed weak consistency (Kappa=0.388, P<0.05). Multivariate logistic regression analysis showed that the positive expression of Survivin was an independent risk factor of RCC (oR=16.256, 95%CI: 1.132~ 233.515, P<0.05). Conclusion: CD147 and Survivin are over-expressed in RCC specimens. CD147 and Survivin may play a crucial stage in development of human RCC. Detection of the expression of CD147 and Survivin can be used in the evaluation of malignant degree and prognosis of RCC.
