Changes of plasma neuroglobin and S-100β protein concentration in patients undergone coronary artery bypass grafting surgery under cardiopulmonary bypass
MIAO Jianxia, WANG Liangrong, ZHAO Xiyue,
Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou,325015
Abstract：Objective: To investigate the changes of plasma neuroglobin and S-100β protein concentrations in patients undergone coronary artery bypass grafting surgery under cardiopulmonary bypass (CPB). Methods:Forty patients, American Association of Anesthesiologists (ASA) and New york Heart Association (NyHA) status II or III, the Mini-Mental State Examination (MMSE, range 0～30) score≥26, undergoing coronary artery bypass grafting surgery with CPB were enrolled. Blood samples were collected immediately at anesthesia induction (T0), CPB re-warming to 36 ℃ (T1) and 1 h (T2), 6 h (T3) and 24 h (T4) after CPB, plasmas were obtained for further determination of neuroglobin and S-100β protein concentration. MMSE were measured preoperatively and three days after operation. Results: Compared with values in T0, the plasma concentrations of neuroglobin and S-100β protein was significantly increased at T2-T4 (P<0.05), with peaking at T3. MMSE scoring at 3 d after operation was lower than preoperative baseline (P<0.05). Conclusion: Cognitive function is impaired and the plasma neuroglobin and S-100β protein levels are increased in patients undergone coronary artery bypass grafting surgery under CPB, these two can be considered as indicators of cerebral injury after cardiopulmonary bypass.
