The relationship between bone density and marrow fat in postmenopausal females with type 2 diabetes#br#
LIN Haiyang1, FENG Xuewen2, MAO Xiaojie1, CHEN Enfu1.
1.Department of Endocrinology, the First People’s Hospital of Wenling, Taizhou, 317500; 2.Department of Neurology, the First People’s Hospital of Wenling, Taizhou, 317500
LIN Haiyang,FENG Xuewen,MAO Xiaojie, et al. The relationship between bone density and marrow fat in postmenopausal females with type 2 diabetes#br#[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(1): 28-32.
Abstract：Objective: To explore the relationship between vertebral bone density (BMD) and marrow fat fraction (FF) in postmenopausal females with type 2 diabetes (T2DM). Methods: Patients with T2DM (49-85 years, n=43) and healthy controls (50-77 years, n=35) underwent DXA and MR spectroscopy scanning to obtain BMD and FF. Blood glucose (FPg), HbA1c, fasting insulin (FINS) and total cholesterol (TC), triglycerides (Tg), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured after fasting for 12 h. Homeostasis model assessment was performed to assess the status of insulin resistance (HoMA-IR). Results: Subjects with T2DM had higher vertebral BMD [(1.103±0.187)g/cm2] and FF(74.1%±16.7%) than those of healthy controls [BMD=(1.015±0.171) g/cm2, FF=63.3%±12.9%, respectively].Even controlling for years of menopause, BMI, FPg, HbA1c, HoMA-IR and blood lipids index, FF in the T2DM group remained higher than that in the control group (F=10.857, P=0.010). FF was inversely correlated to BMD In the control group (r=-0.430, P=0.014) but positively associated with BMD in the T2DM group (r=0.385,P=0.029) after adjustment for the confounders. Conclusion: Despite having higher BMD values, patients with T2DM in postmenopausal females have higher vertebral marrow fat content.
