1.Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 3.Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
XUE Jisen,CHEN Cheng,ZHU Hua, et al. The expression of IL-17 in the cervical cancer with high-risk human papillomavirus infection#br#[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(1): 24-27,32.
Abstract：Objective: To investigate the expression of IL-17 in patients diagnosed as cervical squamous cell carcinoma (SCC) with high-risk human papillomavirus (HPV) infection, with the aim to explore the potential role of specific immune response mediated by IL-17 in the disease progression and carcinogenesis of cervical cancer which is closely associated with high-risk HPV infection. Methods: The study groups included 28 cervical SCC patients with high-risk HPV infection and 25 high-risk HPV infected women with normal cervical cytology. Thirty patients diagnosed as uterine myoma with normal cervical cytology and negative HPV testing were enrolled as the control group. The concentration of IL-17 in serum and supernatant of cervical tissue homogenate were examined with ELISA method. Results: ①The serum concentrations of IL-17 in patients with cervical SCC were significantly higher than those in the control group (P<0.05), but there was no significant difference observed between SCC group vs the high-risk HPV infection group (P>0.05) and the high-risk HPV infection group vs the control group (P>0.05); ②The average concentrations of IL-17 in supernatant of cervical tissue homogenate of all groups were obviously higher than those in serum respectively (P<0.05); ③The concentrations of IL-17 in supernatant of cervical tissue homogenate differed significantly among the study groups and the control group (P<0.05). The concentrations in the cervical SCC group were higher than those in the high-risk HPV infected group, which were much higher than the control group (P<0.05). Conclusion: These results indicate that the immune reaction mediated by IL-17 may participate in and promote the persistent infection of high-risk HPV,which is closely associated with the disease progression and carcinogenesis of cervical cancer cervical cancer.
