WANG Xiangyun,YIN Weiyong,ZHOU Chengye.. Interrelation between insulin resistance and intracanial arterial stenosis in patients with cerebral infarction[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(12): 899-.
Abstract：Objective: To evaluate the relationship between insulin resistance and intracanial arterial stenosis in patients with cerebral infarction. Methods: Two groups were studied: ①161 patients with potential intracanial arterial stenosis (grade≥50%, at least one vessel); ②81 subjects without intracanial arterial stenosis (grade<50%). Insulin resistance was determined by the steady state model evaluation method, special tool was used to calculate the evaluation index of insulin resistance. MRI and MRA was performed in all subjects. The severity of intracanial arterial stenosis was determined by the Warfarin-Aspirin Symptomatic Intracranial Disease Study (WASID). Results: The homeostasis model assassment 2-insulin resistance (HOMA2-IR) was significantly higher in patients with intracanial arterial stenosis compared with control subjects. Based on logistic regression model, high HOMA2-IR was one of the risk factors. Conclusion: These results suggest that insulin resistance is a risk for intracranial arterial stenosis.
