SUN Guangzheng,WU Yilei,ZHANG Haifeng, et al. Expression of nectin-4 in hepatocellular carcinoma and its clinical significance[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(12): 887-.
Abstract：Objective: To study the nectin-4 expressions in hepatocellular carcinoma (HCC) and its clinical significance. Methods: The nectin-4 expression in 36 pairs of HCC tissues, and 10 samples of normal liver tissues were detected with immunohistochemical techniques. The relations of nectin-4 expression with the clinicopathologic parameters were analyzed. Results: The IOD and area of nectin-4 were 2.55±0.64 and 8.96±1.57 in hepatocellular carcinoma tissues, which were significantly higher than those in the normal liver tissues (P<0.01). The expression of nectin-4 was not correlated with patients demographics (P>0.05), and the protein expression was correlated with histopathologic grade (P<0.01) and lymph metastasis (P<0.05). Conclusion: The high expression of nectin-4 in hepatocellular carcinoma tissues suggests that its high expression may be correlated with the malignant degree of the carcinoma, nectin-4 can be considered as a reference index of differentiation, metastasis and prognosis in hepatocellular carcinoma.
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