YE Xiaojiao,LOU Pengcheng,JIN Jiangbing, et al. The nosocomial septicemia in children: A 10-year analysis of etiology and morbidity changes[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(11): 834-.
Abstract：Objective: Investigate the clinical features and morbidity of nosocomial septicemia in children. Anlyse pathogenic bacteria and antibiotic resistance of these infections to improve the control and treatment. Method: A total of 68 patients of nosocomial septicemia in Yuying Children’s Hospital from January 2005 to December 2014 were enrolled in the retrospective study. Results: The infection rate of nosocomial septicemia (non-neonates) was 0.054% in Yuying Children’s Hospital during 10 years. Which was totally 0.091% durling 2005-2009, statistically significant higher than 0.035% durling 2010-2014 (x2=16.530, P=0.000). 70 strains of pathogens were isolated from blood in 10 years. In which gram-positive bacteria accounted for the highest proportion (35 strains, 50%), gram-negative bacterial was 42.9% (30 strains), pathogenic fungi was 7.1% (5 strains). The predominant three pathogens of G+ bacteria were coagulase negative staphylococci, oral streptococci and staphylococcus aureus. The predominant four pathogens of G- bacteria were escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa and Salmonella. Escherichia coli, klebsiella pneumoniae and pseudomonas aeruginosa were found to have multidrug resistance. Conclusion: The infection rate of nosocomial septicemia (non–neonates) was 0.054% in Yuying Children’s Hospital which Affiliated to Wenzhou Medical College during 2005-2014. This infection rate has a decrease trend during 2005-2014 (x2=16.530, P=0.000). Gram-positive bacteria were the major pathogens in nosocomial septicemia in children (non-neonates). There was no significant difference in pathogenic bacteria proportion between 2005-2009 and 2010-2014.
