维持性血液透析患者睡眠障碍与脂肪细胞因子水平相关关系

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摘要目的：寻找维持性血液透析（MHD）患者中细胞因子水平与睡眠障碍间的潜在的关系，从而为血透患者睡眠障碍影响心血管疾病发生的机制探讨提供参考。方法：选择我院肾脏内科血液透析中心2013年1月-2014年8月透析时间超过3个月且病情比较稳定的MHD患者82例，根据匹兹堡睡眠质量指数（PSQI）积分分为睡眠障碍组（PSQI＞5，n=56）和对照组（PSQI≤5，n=26）。2组于血透前检测血尿素氮、血肌酐、血白蛋白、C反应蛋白（CRP）、瘦素、血白介素（IL）-6。对2组患者上述指标进行统计学分析。结果：2组患者性别和年龄差异均无统计学意义（P＞0.05），但睡眠障碍组患者CRP、瘦素较对照组更高，2组比较差异有统计学意义（P＜0.05）。结论：血液透析患者的睡眠障碍与脂肪细胞因子水平存在相关关系。

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Abstract：Objective: Look for the potential relationship between the level of adipose cytokines and sleep disorders in maintenance hemodialysis (MHD) patients, so as to explore the mechanism of sleep disorders affecting cardiovascular disease. Methods: Eighty-two cases of MHD patients with dialysis more than 3 months were chosen in our hemodialysis center from January 2013 to August 2014 as the study group, and were divided into two groups according to PSQI score (PSQI≤5 and PSQI>5). Urea, creatinine, albumin, CRP, leptin, interleukin-6 specimens were measured in two groups before hemodialysis. Statistical analysis was performed on two groups of patients with these indicators. Results: Sex and age in two groups had no significant difference (P>0.05). But CRP and leptin in sleep disorder groups were higher than the control group, there was statistical difference (P<0.05). Conclusion: Sleep disorder correlated to the level of adipose cytokines in hemodialysis patients.

Key words： maintenance hemodialysis sleep disorders leptin C-reative protein

收稿日期: 2015-02-16

基金资助:温州市科技局科技计划项目（Y20140286）。

作者简介: 张一帆（1978-），男，浙江温州人，主治医师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2015/V45/I11/831

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