男性酒精依赖患者认知功能与红细胞参数的相关性分析

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摘要目的：探讨男性酒精依赖患者是否存在认知损伤及其与红细胞参数之间的相关性。方法：采用重复性成套神经心理状态测查量表（RBANS）对60例成年男性的认知功能进行评估，其中酒精依赖患者30例，正常受试者30例，并检测红细胞参数。利用方差分析比较酒精依赖组认知功能及红细胞参数与对照组的差异，并采用pearson相关分析探索酒精依赖患者认知功能与红细胞参数间的相关性。结果：即刻记忆、视觉空间、语言功能、注意、延迟记忆和RBANS总分在酒精依赖组和对照组之间差异具有统计学意义（均P＜0.01）；酒精依赖组与对照组相比，红细胞计数显著降低，平均红细胞体积显著增大，差异有统计学意义（均P＜0.01）。酒精依赖组红细胞计数与延迟记忆呈正相关（P＜0.01）；平均红细胞体积与语言功能（P＜0.05）、延迟记忆（P＜0.01）、RBANS总分呈负相关（P＜0.05）。结论：男性酒精依赖患者存在认知损伤，并且红细胞计数和平均红细胞体积对其认知损伤具有显著影响。

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关键词 ：酒精依赖, 男性, 认知功能, 红细胞参数

Abstract：Objective: To investigate whether male alcohol-dependent patients had cognitive impairments, and cognitive impairments were correlated with erythrocyte parameters in male alcohol-dependent patients. Methods: Sixty adults male, including 30 alcohol-dependent patients and 30 healthy controls in Wenzhou Kangning Hosipital Affiliated to Wenzhou Medical University were enrolled. Cognitive functions in all subjects were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Erythrocyte parameters were examined in all subjects. Analysis of variance was conducted to explore difference in both cognitive functions and erythrocyte parameters between alcohol-dependent patients and controls, and the influence of erythrocytes, mean corpuscular volume and hemoglobin on cognitive functions in alcohol-dependent group were examined using pearson correlation analysis. Results: There were significantly difference in immediate memory, visuospatial, language, attention, delayed memory and total score of RBANS between alcohol-dependent patients and controls (all, P<0.01). Alcohol-dependent group had lower erythrocytes and higher mean corpuscular volume compared to controls (both, P<0.01). There was a positive correlation between erythrocytes and delayed memory (P<0.01). Mean corpuscular volume was negatively correlation with language (P<0.05), delayed memory (P<0.01), and total score of RBANS (P<0.05). Conclusion: Male alcohol-dependent patients have cognitive impairments. Moreover, erythrocytes and mean corpuscular volume influence cognitive impairments in male alcohol-dependent patients.

Key words： alcohol dependence male cognitive functions erythrocyte parameters

收稿日期: 2015-04-22

基金资助:浙江省医药卫生科技计划项目（2015KYB368）；温州市公益性科技计划项目（Y20140478）；温州市医药卫生项目（2014A11）。

通讯作者: 唐闻捷，研究员，硕士生导师，Email：13606777777@qq.com。

作者简介: 郑克（1983-），男，浙江温州人，硕士生。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2015/V45/I11/799

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