Clinical and pathological features of elder patients with idiopathic membranous nephropathy
1.The First Clinical School, Wenzhou Medical University, Wenzhou, 325035; 2.Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
CHEN Yu1,CHEN Xinxin2,HUANG Chaoxing2.. Clinical and pathological features of elder patients with idiopathic membranous nephropathy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(10 ): 769-.
Abstract：Objective: To investigate the clinical and pathological features of elder patients with idiopathic membranous nephropathy (IMN). Methods: One hundred and fifty patients with IMN were diagnosed by renal biopay in our hospital from Jun 2006 to Dec 2013, the relationship between clinical and pathological features were retrospectively analyzed on the basis of age, including older age group (≥60 s) 86 cases and jnvenile group (≤35 s) 64 cases. Results: Compared with jnvenile group, there were high incidence rates of hypertension, edema, renal insufficiency, diabetes and infections in the older age group. There were also significant statistical differences among course of disease, BUN, Scr, UA, Alb, TC, Fib, and Ccr in two groups. Most cases were classified as stage I or II membranous lesions in pathology. Compared with jnvenile group, there were high incidence rates in focal segment glomerulosclerosis, tubule-interstitial pathological changes, arterioles sclerosis and arteriole hyaline degeneration in the older age group. Conclusion: Elder IMN patients usually have complications with hypertension, diabetes, renal insufficiency, infections and tubule-interstitial and arterioles chronic pathological changes. More attentions should be paid to early diagnosis of IMN in elder patients, and take pertinence actions.
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