WANG Xiaodong,CHEN Jian,LIU Jian, et al. Contrastive analysis between depression with chief complaint of xerostomia and Sjögren’s syndrome[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(10 ): 728-.
Abstract：Objective: To investigate the difference between depression with chief complaint of xerostomia and Sjögren’s syndrome (SS) by analyzing the clinical characteristics. Methods: The peripheral blood white cells, neutrophilic granulocytes, lymphocytes, CRP, immune globulin (Ig), auto antibodies, labial salivary gland biopsy, and parotid gland ECT in depression with chief complaint of xerostomia group, SS group, SS complicated with depression group and healthy people were evaluated respectively. Statistical analysis was used to find the difference between each group. Results: The peripheral blood white cells was lower in the depression group than that in the healthy control group (P<0.01), and the depression play a main effect on peripheral blood white cells. The CRP was higher in the depression group than the healthy control group (P<0.01), while there was no significant difference between the other two groups. The IgG level was the lowest in the four groups (P<0.05). The IgA and IgM level was higher in SS group and SS with depression group (P<0.01). SS played a main effect on increasing IgM and IgA. Although the positive rate of RF was lower in the depression group than that in SS and SS with depression group, there was no significant difference. The pathdogical examination did not find of small labial positive in the depression and healthy control group. Conclusion: In patients with the chief complaint of xerostomia with depression humoral immune abnormalities and acute inflammation also exists. These patients may be misdiagnosed as SS, if necessary, we must do small labial gland biopsy to be identified.
