Effect of dexmedetomidine on hepatic function in patients undergone laparoscopic cholecytectomy with CO2 pneumoperitoneum
1.Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 2.Department of Anesthesiology, the Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200
CHEN Li1,2,LU Bin2, et al. Effect of dexmedetomidine on hepatic function in patients undergone laparoscopic cholecytectomy with CO2 pneumoperitoneum[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(9): 687-.
Abstract：Objective: To evaluate the effect of dexmedetomidine on hepatic function in patients undergone laparoscopic cholecystectomy with CO2 pneumoperitoneum. Methods: Sixty patients aged 18–60 years, whose pneumoperitoneum duration varied from 0.5 to 1 h and matched ASA I-II, were randomly divided into two groups: control group (group C, n=30) and dexmedetomidine group (group D, n=30). In group D, dexmedetomidine was infused intravenously at a rate of 1 μg•kg-1 for 10 min, followed by 0.3 μg•kg-1•h-1 until the end of the operation, while in group C equal volume of 0.9% sodium chloride solution was infused after trachea intubation. Peripheral vein blood samples were collected immediately before anesthesia (T0, baseline), 1 h (T1) and 24 h (T2) after pneumoperitoneum released for measurement of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), plasma IL-6, TNF-α, malondialdehyde (MDA) and superoxide dismutase (SOD) levels. Results: Compared with T0 point, the serum ALT, AST activities were significantly increased at T2 in both groups. Compared
with group C, the serum ALT, AST, plasma TNF-α and IL-6 were significantly descreased at T2 and the serum MDA was significantly descreased at T1, T2 and the levels of plasma SOD at T1 was significantly increased in group D (P<0.05). Conclusion: Hepatic injury in patients undergone laparoscopic cholecystectomy with CO2 pneumoperitoneum can be attenuated by dexmedetomidine via inhibiting inflammatory responses and lipid peroxidation.
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