TAO Xiaoxiao,WANG Peng,JIN Yunlong, et al. The influence of different loading doses of Urapidil injection on blood pressure and the door-to-needle time in acute ischemic stroke[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(9): 671-.
Abstract：Objective: To observe the effect of different doses of Urapidil injection before thrombolysis in acute ischemic stroke on the blood pressure or door-to-needle time (DNT). Methods: Thirty-six cases in our hospital who were treated with Urapidil injection before intravenous t-PA treatment were retrospectively analyzed and were divided into 3 groups A, B, C according to the loading dose. Group A was with a loading dose of 5 mg Urapidil injection, Group B was with a loading dose of 12.5 mg, and Group C was with a loading dose of 25 mg. At last, shrinkage pressure (SBP), diastolic blood pressure (DBP), DNT and 3-month MRS score among the three groups were compared. Results: Compared to group A in which SBP was (173.27±6.92) mmHg and DBP (81.73±7.71) mmHg, the blood pressure of group B, with SBP (165.80±7.76) mmHg and DBP (80.93±6.95) mmHg, and group C, with SBP (154.80±10.69) mmHg and DBP (73.60±5.13) mmHg, decreased significantly (P<0.001). Compared to group A with (89.00±25.76) min, the DNT of group B with (76.73±20.20) min and group C with (73.10±14.15) min the door-to-needle time (DNT) significantly reduced (P<0.001). In addition, the percentage of MRS scores (0-1 points scale) after three months in group B (60.0%) was the highest among the three groups (P<0.001). Conclusion: Urapidil injection with the first load of 12.5 mg can effectively decrease blood pressure to standard as soon as possible with a better outcome.
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