MAO Xinlei,HAN Liya,HUANG Xiangdong, et al. The correlative analysis of eNOS rs1799983 single-nucleotide polymorphisms and cerebral infarction[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(9): 652-.
Abstract：Objective: To investigate the relationship of eNOS rs1799983 single-nucleotide polymorphisms (SNP) and cerebral infarction. Methods: Data was prospectively collected from consecutive ischemic stroke inpatients in neurology department of our hospital from may 2014 to september 2014. Eighty-three large-artery atherosclerosis (LAA) patients and small-artery occlusion (SAO) patients in 100 patients were enrolled, according to the TOAST criteria. The control group was 91 subjects from the Medical Examination Center at the same period. Taqman probe technique was used for the detection of eNOS rs1799983 SNP. The clinical characteristics and eNOS rs1799983 SNP were compared between three groups. Results: As compared with the controls, there were statistically significant differences in percentage of HBP, smoking, drinking, high-density lipoprotein and cholesterol concentrations in LAA and SAO groups (P<0.01). The GG genotype was main genotype in three groups. Only 1 case TT genotype was observed in LAA group. The frequency of allele and genotype was not significantly difference in these three groups. Conclusion: It is suggested that there are similar risk factors in LAA and SAO patients. The eNOS rs1799983 SNP maybe unrelated to cerebral infarction.
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