YU Lingfang,CHEN Minguang,YANG Qing, et al. Clinical analysis of curative effects of urinary tract infection in children caused by Escherichia coli[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(7): 534-.
Abstract：Objective: To summarize the curative effects of the antibiotics used for the treatment of the urinary tract infection (UTIs) in children caused by Escherichia coli and to provide the basis for empirical therapy. To discuss the associated risk factors of UTIs caused by Extended-Spectrum β-Lactamase (ESBLs)-producing Escherichia coli which was no response to the cephalosporin antibiotics therapy. Methods: The treatment outcomes of 112 UTIs caused by Escherichia coli from 2011, January to 2012, December in our hospital were analyzed. Results: Effective power was 100%, if according to antibiotic susceptibility testing. The curative effect of empiric therapy for non-ESBL UTIs was also perfect. However, the curative effect of empiric therapy for ESBL UTIs was suboptimal, cephalosporin antibiotics was only 63.27%, β-Lactamase inhibitors combined drugs or carbopenems were nearly 100% for ESBL UTIs patients. In the subgroup of empiric therapy for ESBL UTIs with cephalosporin antibiotics, the no-response group had higher level of C-reactive protein, white blood count, higher rate of urinary tract anomalies, microalbumin and β2-microglobulin, when compared with response group. Conclusion: Empiric therapy by the third generation cephalosporin should be cautious for the patients with urinary tract anomalies, high level of inflammatory markers, microalbumin or β2-microglobulin, while β-Lactamase inhibitors combined drugs could be optional. However, in refractory and severe cases, carbopenems antibiotics are recommended.
