ZENG Tingting,WU Zhiping,ZENG Min, et al. Correlative study on the rapid-eye-movement sleep behavior disorder and cognitive impairment of Parkinson’s disease[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(6): 434-.
Abstract：Objective: To investigate the correlation between rapid-eye-movement sleep behavior disorder (RBD) and the cognitive impairment in patients with Pakinson disease (PD). Methods: Fifty-four patients with Parkinson disease were enrolled from Neurology Department of Lishui Central Hospital from 2012 to 2013 (25 PD-RBD cases and 29 PD-NRBD cases), with 21 healthy participants as the control group. Full-night video- polysomnography (vPSG) for two nights, Unified Parkinson Disease Rating Scale (UPDRS-III) Questionaire, Hoehn-Yahr stage criteria, Montreal Cognitive Assessment (MoCA) and The Epworth Sleepiness Scale (ESS) were performed on all study participants. Results: The score for attention and calculation, visual-spatial and its congitive function, delayed memory in PD-RBD group were all significantly lower than that in PD-NRBD group and control group (P<0.05). Sleep efficiency in both PD-RBD and PD-NRBD group were lower than that in control group, and often accompanied by obstructive sleep apnea-hypopnea syndrome and restless leg syndrome (P<0.05). There was no statistical significant difference between the two PD groups (P>0.05). Conclusion: Parkinson disease patients combined with RBD are correlated with cognitive dysfunction. RBD can be used as a predictor for cognition impairment in Parkinson disease.
