CHI Haihong,ZHANG Huina,LU Xiaosheng, et al. Application of vaginal 17β-estradioltion administration in endometrial preparation for patients undergoing frozen-thawed blastocyst transfer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(6): 413-.
Abstract：Objective: To investigate the relationship between pregnancy and serum estradiol (E2) levels, endometrial thickness, endometrial pattern in patients using vaginal administration of 17β-estradiol in frozen-thawed embryo transfer (FET). And to analyze the effect of using the different dose of 17β-estradiol on serum (E2) levels, endometrial thickness, endometrial pattern and pregnancy rate. Methods: A total of 90 patients of anovulia induced barrenness were undergone frozen embryo transfer in the Reproduction Medical Center of the Second Affiliated Hospital of Wenzhou Medical University from June 2013 to May 2014. The relationship between serum estradiol (E2) levels, endometrial thickness and endometrial pattern was investigated in two groups including pregnant group (n=49) and non-pregnant group (n=41) according to clinical outcome. All the patients were divided into two groups: group A (vaginal estrogen 1 mg) and group B (vaginal estrogen 2 mg). The difenrences of their sesum E2 levels, endometrial thickness, endometrial pattern and pregnancy rate were compared between the two groups. Results: The clinical pregnancy rate was 54.00% (49/90), the implantation rate was 34.71% (59/170). There were no satistical diffefence in patients’ age, infertile years, endometrial thickness of uterus, number of embryos transferred, E2 and P levels on the day injection of progesterone and on transplant day between pregnant group and non-pregnant group. The proportion of type A endometrium in pregnant group were significantly higher than that in non-pregnant group (P<0.05). E2 levels on injection of progesterone, E2 levels on transplant day were significantly lower in group A compared with group B (P<0.05). No significant difference were shown in the mean of endometrial thickness of uterus, endometrium patterns, P levels ontransplant day, the clinical pregnancy rate and the implantation rate. Conclusion: Our study shows that it is suitable for patients with anovuliain frozen embryo transfer cycle through hormone supplyment therapy with vaginal administration of 17β-estradiol, and the serum E2 levels, endometrial thickness and clinical pregnancy rates could achieve satisfactory results.estrodiol and dydroesterone of femoston in FET cycle. 17β-estrodial 1mg can reach to 2 mg of endometral thickness and pregnancy rate. The protocol is simple and feasibility. The endometrium pattern is one of the important factorsaffect pregnancy rates.
