LUO Huarong,XU Cheng,ZHENG Haihong, et al. Clinicopathological features of solid papillary carcinoma of the breast[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(5): 364-.
Abstract：Objective: To investigate the clinicopathological features of solid papillary carcinoma (SPC) of the breast. Methods: A study was performed to analyse the clinical and pathological manifestations in 18 cases of SPC. Immunohistochemical staining for ER, PR, CerbB-2, Ki-67, CK5/6, CK14, P63, Syn and CgA was performed. And the expression of HER-2 gene amplification was detected by fluorescence in situ hybridization. Results: All the tumors presented as a palpable, centrally located mass or as bloody nipple discharge. Histologically, the tumor was comprised of multiple circumscribed expansile nodules with delicate fibrovascular cores. 55.6% of these tumors had extracellular or intracellular mucin and 16.7% was associated with invasive carcinoma. Immunohistochemically, all tumor cells were strongly positive for ER and PR. CerbB-2 was negative in the most cases except for 4 cases with weak expression. All cases were negative for CK5/6, CK14 and P63 in the cellular nodules. Peripheral myoepithelium was complete in 9 cases, discontinued in 5 cases and loss in 4 cases. The positive expression rates of Syn and CgA were 72.2% and 55.6%, respectively. The average positive rate of Ki-67 in tumor cells was 8.5%. None of 3 cases with invasion had HER-2 gene amplification. One of 17 cases with axillary lymph node dissection or sentinel lymph node biopsy had axillary lymph node metastasis at operative time. And none of 17 patients (94.4%) followed up had tumor recurrence and metastasis. Conclusion: SPC is a rare breast cancer, predominantly found in elderly females, with distinctive histological morphology and immunophenotype. Clinicopathological features and follow-up data suggest that SPC often carries an indolent clinical behavior and favorable prognosis.
