MAO Chuanwan,FU Yuchuan,MAO Yiting, et al. Application of 3D-pcASL magnetic resonance imaging in the diagnosis of acute cerebral apoplexy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(5): 350-.
Abstract：Objective: To assess the applied value of the three-dimensional pseudo-continuous arterial spin labeling (3D-pcASL) technique in MRI Perfusion-weighted imaging in acute ischemic stroke. Methods: DWI and 3D-pcASL technique were be performed in thirty-nine patients suspected ischemic stroke and the onset time for 7 days. The findings of the lesions in acute cerebral infarction patients on 3D-ASL images and conventional DW images were observed. Then, the CBF values of the lesions and the contralateral symmetrical brain regions were measured. Results: Among the 39 cases, 34 cases were diagnosed as cerebral infarction during follow-up, 5 cases with TIA. In the 21 of 34 patients with cerebral infarction, the lesions were located at the gray matter, and showed low perfusion on 3D-pcASL images. The mean CBF values of these lesions were 16.7±12.2 mL·min-1·
100 g-1, and were lower than that at the contralateral area 44.8±13.9 mL·min-1·100 g-1 (P<0.01); In the other 13 cases, the lesions only involved in the white matter, the CBF values of these lesions weren’t measured for their poor differentiation with the white matter on 3D-pcASL images, in the 5 TIA patients, the lesions of 3 cases showed low perfusion on the 3D-ASL images. The mean CBF values of the affected regions were 37.6±4.4 mL·min-1·100 g-1, 58.8±10.6 mL·min-1·100 g-1 in the contralateral areas. In 34 cases of cerebral infarction patients, the lesions in DWI all showed high signal. However, the lesions were detected only in 21 cases on the 3D-ASL images, the area of the lesions on 3D-pcASL images was larger than that on the DWI in 17 of 21 patients. The singal was normal on DWI in the 5 TIA patients. Conclusion: The 3D-pcASL technique can provide localization, qualitative and quantitative diagnosis in ischemic stroke patients with the lesions located at gray matter. It can also discover that the TIA patients show normal on DWI. However, this technique has some limitations in the detection of ischemic lesions in the white matter.
