The clinicopathological and diagnostic analystic in 49 cases cervical adenocarcinom
1.Department of Pathology, Dongyang Maternity and Child Care Centers, Jinhua, 322100; 2.Department of Obstetrics and Gynecology, Hengdian Hospital, Jinhua, 322118; 3.Department of Cervical Diagnosis Center, Dongyang Maternity and Child Care Centers, Jinhua, 322100; 4.Department of Pathology, Dongyang People’s Hospital, Jinhua, 322100
JIN Xinhong1,WENG Ke2,WANG Shanshan3, et al. The clinicopathological and diagnostic analystic in 49 cases cervical adenocarcinom[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(4): 290-.
Abstract：Objective: To investigate the clinical and pathological features of cervical adenocarcinoma and analyze the relevant factors which leading to misdiagnosis and missed diagnosis, aimed at early diagnosis and affirm the histological type. Methods: Clinical and pathological data of 49 cases of cervical adenocarcinoma patients, comprehensive combing the treatment and diagnosis process of all cases were retrespefively analyzed. Results: The cervical adenocarcinoma percentage of cervical cancer was 20.47% and 10.11% in 2011～2013 and 2005～2007. The main clinical symptoms of cervical adenocarcinoma were vaginal bleeding, fluid flow and increased vaginal discharge. Liquid-based cytology false negative rate was 28.57% (18/49). High-risk HPV positive rate was 93.88% (46/49). The first biopsy-confirmed cases were only 21 cases (46.94%). The pathology grossly type was mainly about nodular polypoid or endophyte, but that there were 11 cases (22.45%) was cervicitis or cervical smooth performance. The mucinous adenocarcinoma was the most to see of histology. Immunohistochemical CEA, P16 and P53 were positive. Conclusion: The meyority of clinicd syrptoms of the cervical adenocarcinama was non-specific. Utilization ofliquid-based cytology, high-risk HPV testing, colposcopy, cervical cone biopsy and immunohistochemical examination and other means to effectively master a variety of diagnostic genotyping points is the key to reducing misdiagnosis and miss diagnosis. Suggested that cervical conization as a diagnostic method for the micro-deviation adenocarcinoma, fluff tubular adenocarcinoma, cervical adenocarcinoma and early invasive adenocarcinoma.
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