Analysis of characteristics of non-Helicobacter pylori and non-NSAID peptic ulcer disease
1.Department of Gastroenterology, Wenzhou People’s Hospital, Wenzhou No.3 Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, 325000; 2.Department of Ultrasound, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
ZHENG Endian1,NI Shuangshuang2,LIN Xizhou1, et al. Analysis of characteristics of non-Helicobacter pylori and non-NSAID peptic ulcer disease[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(4): 286-.
Abstract：Objective: To expplore the characteristics of non-Helicobacter pylori (Hp) and non-NSAID peptic ulcer disease. Methods: A total of 473 cases with peptic ulcer disease were recruited in the study between 2011 and 2013. Hp status was assessed by histology and/or 13C-urea breath test. These cases were divided into group of non-Hp and non-NSAID peptic ulcer disease (group A), group of Hp positive only (group B), group of NSAID only (group C) and group of Hp positive and NSAID (group D). The proportion of non-Hp and non-NSAID peptic ulcer disease (group A), Gender and ages of these patients were collected. The characteristics of group A, group B, group C and group D were analyzed and compared. Results: Fifty six patients with non-Hp and non-NSAID peptic ulcer disease (group A) were diagnosed and the proportion was 11.8% (56/473). There was no significant difference between group A and other groups in distribution of gender (P>0.05). There was significant difference between group A and group B in distribution of age (P<0.05). There was no significant difference between group A and other groups in clinical symptoms, such as abdominal pain, abdominal distension and so on (P>0.05). There was significant difference between group A and group D in gastrointestinal bleeding (P<0.05).There was significant difference among group A,group B, group C and group D in abdominal tenderness (P<0.05). The rate of smoker in group A was significantly higher than that of the other groups (all P<0.05). The proportions of ulcer at stomach and single ulcer of group A were significant higher than that of group B (P<0.05).There were no significant difference among the four groups in sizes of ulcer (P>0.05). Conclusion: Non-Hp and non-NSAID peptic ulcer disease has an important proportion among peptic ulcer disease, the patients are old and the tenderness was common. The proportions of fudus of stomach and single ulcer are significant higher than that of the group of Hp positive only. Smoking is one of the possible causes of non-Hp and non-NSAID peptic ulcer disease.
