ZHENG Shubei,JIN Lingwei,ZHOU Zhihong. Serum secretory Klotho is associated with coronary atherosclerosis in patients on maintenance hemodialysis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(4): 281-.
Abstract：Objective: To determine the relationship between serum secretory Klotho and coronary atherosclerosis in maintenance hemodialysis (MHD) patients. Methods: One hundred and fifty-two cases of MHD patients, who were underwent coronary artery angiography, were collected prospectively. Serum secretory Klotho was detected by ELISA. Coronary artery lesions involving the count and Syntax score were recorded by the result of coronary angiography examination. Logistic regression analysis was used to determine the risk factor of coronary atherosclerosis in MHD patients. The ROC analysis was applied to evaluate the diagnostic value of secretory Klotho in coronary atherosclerosis. Results: Eigty-one patients had coronary atherosclerosis. Serum secretory Klotho concentration was negatively correlated with coronary atherosclerosis (r=-0.260, P=0.001). Secretory Klotho and counts of coronary artery lesion showed a negative correlation (r=-0.268, P=0.001). Secretory Klotho was also negatively correlated with Syntax score (r=-0.223, P=0.046). Logistic regression analysis showed that lower secretory Klotho level was an independent risk factor for coronary atherosclerosis (OR=3.125, 95%CI 1.298～7.522). ROC-AUC of serum secretory Klotho for coronary atherosclerosis was 0.650 (cut off 373.825 pg/mL, accuracy 81.7%, specificity 44.4%). Conclusion: Serum secretory Klotho of MHD patients is associated with coronary atherosclerosis, and is negatively related to the severity of coronary atherosclerosis, also is an independent risk factor in MHD patients with coronary atherosclerosis. Serum secretory Klotho may have diagnostic value for coronary atherosclerosis in MHD patients, and can judge the severity of coronary artery lesions.
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