ZHOU Weizhong1,FU Hongxing2,WU Lanlan1, et al. Preparation and in vitro quality evaluation of a small type of compound rapamycin suppositories[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(4): 278-.
Abstract：Objective: To develop a small type of suppository of immunosuppressive agents to suit for large animals after abdominal organ transplantation, and carry out it’s quality evaluation. Methods: Rapamycin and tacrolimusas were chosed as active pharmaceutical ingredients, and polyethylene glycol 2000, polyethylene glycol 4000 were used as substrate. Melting followed with a quantitative injection molding process was used to prepare the small type of compound suppository. The appearance, weight difference, melting time and drug content of the suppository were evaluated. Results: The compound rapamycin suppository was translucent, white, and had good hardness at room temperature. It’s short, and the weight variation, melting time and drug content were conformed to the requirements of the suppository. Conclusion: The compound rapamycin suppository prepared by this method conforms to the quality of suppository, which makes a good foundation for the development of the new drug.
