CHEN Songfang,LI Lifeng,CHEN Jing, et al. The antidepressant effect of procyanidins extract from Zanthoxylum bungeanum Maxim on ovariectomized model mice[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(4): 260-.
Abstract：Objective: To explore the antidepressant effect of chronic pre-administration with procyanidins extract from Zanthoxylum bungeanum Maxim (ZPPC) on ovariectomized model mice and its possible mechanism. Methods: The animals behavioral despair models of depression, including the tail suspension and forced swimming tests, were used to explore the antidepressant effects of ZPPC. The locomotor activity test was used to detect the change of locomotor activity. Meanwhile, the monoamine oxidase activity in the mouse brain was also determined. Results: The results showed that ZPPC (50, 100, 200 mg/kg) significantly reduced the duration of immobility in both tail suspension and forced swimming tests. The effective doses did not alter locomotot activity,
resembling the selectivity of the positive control drug fluoxetine (10 mg/kg) in relieving depression. Moreover, ZPPC was found to inhibit monoamine oxidase activity in the mouse brain. Conclusion: These findings suggest that ZPPC exerts antidepressant effect in animals behavioral despair tests and the underlying mechanism may involve the central monoaminergic systems.
[1] Immadisetty K, Geffert LM, Surratt CK, et al. New design strategies for antidepressant drugs[J]. Expert Opin Drug Discover, 2013, 8(11): 1399-1414.
[2] Patten SB. The Global Burden of Disease 2010 update: keeping mental health in the spotlight[J]. Epidemiol Psychiatr Sci, 2014, 23(3): 255-257.
[3] Soares CN. Depression in peri-and postmenopausal women: prevalence, pathophysiology and pharmacological management[J]. Drugs Aging, 2013, 30(9): 677-685.
[4] Checkley S.The neuroendocrinology of depression and chronic stress[J]. Br Med Bull, 1996, 52(2): 579-617.
[5] Hepgul N, Cattaneo A, Zunszain PA, et al. Depression pathogenesis and treatment: what can we learn from blood mRNA expression[J]? BMC Med, 2013, 5(12): 11-28.
[6] 朱洁瑾, 廖守法, 赵乐萍, 等. 姜黄素对慢性应激模型大鼠学习记忆能力的影响[J]. 温州医学院学报, 2011, 41(5): 462-465.
[7] Schloss P, Henm FA. New insights into the mechanisms of antidepressant therapy[J]. Pharmacol Ther, 2004, 102(1): 47-60.
[8] 袁娟丽, 王四旺. 花椒的化学成分及其药效学研究[J]. 现代生物医学进展, 2010, 10(3): 552-554.
[9] Zhang LM,Wang HL, Zhao N, et al. Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of the total flavonoids extracted fromXiaobuxin-Tang[J]. Neurosci Lett, 2014, 75(11): 31-36.
[10] Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial[J]. Phytother Res, 2014, 28(4): 579-585.
[11] Porsolt RD, LePichon M, Valfre N. Depression:A new animal model sensitive to antidepressant treatment[J]. Nature, 1977, 266(5604): 730-732.
[12] Steru L, Chermat R, Thierry B, et al. The tail suspension test: a new method for screening antidepressants in mice[J].Psychopharmacology (Berl), 1985, 85(3): 367-670.
[13] Schmidt PJ, Haq N, Rubinow DR. A longitudinal evaluation of the relationship between reproductive status and mood inperimenopausal women[J]. Am J Psychiatry, 2004, 161(12): 2238-2244.
[14] Vega-Rivera NM, López-Rubalcava C, Estrada-Camarena E, et al. The antidepressant-like effect of ethynyl estradiol is mediated by both serotonergic and noradrenergic systems in the forced swimming test[J]. Neuroscience, 2013, 250: 102-111.
[15] Mulinari S, Monoamine theories of depression: historical impact on biomedical research[J]. J Hist Neurosci, 2012, 21(4): 366-392.
[16] Hamon M, Blier P. Monoamine neurocircuitry in depression and strategies for new treatments[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 1(45): 54-63.
[17] Shulman KI, Herrmann N, Walker SE. Current place of monoamine oxidase inhibitors in the treatment of depression[J].CNS Drugs, 2013, 27(10): 789-797.
[18] Schmldt PJ, Purdy RH, Uoore PH, et al. Circulating levels of anxiolytie steriods in the luteal phase in women with premenstrual syndromeand in control subjects[J]. Clin Endocrinal Metal, 1994, 79(5): 1256
[19] 张巍, 郭锡永, 刘景英, 等. 更年期妇女抑郁症状与血清孕激素、叶酸、五羟色胺的相关性研究[J]. 中国妇幼保健, 2006, 21(17): 2433-2436.
[20] Sánchez MG, Morissette M, Di Paolo T. Oestradiol modulation of serotonin reuptake transporter and serotonin metabolism in the brain of monkeys[J]. J Neuroendocrinol, 2013,25(6): 560-569.
