The applied value of combined ditection of serum YKL-40 and SCCag in cervical cancer
1.Department of Gynecology, the Third Clinical College of Wenzhou Medical University, Wenzhou, 325000; 2.Department of Gynecology, the Second
Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
DONG Xiaoxia1,HUANG Lingxiao1,LV Jieqiang2, et al. The applied value of combined ditection of serum YKL-40 and SCCag in cervical cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(3): 205-.
Abstract：Objective: To explore the applied value of combined ditection of serum YKL-40 and SCCag levels in cervical cancer. Methods: Enzyme-linked Immunosorbent Assay (ELISA) technique was applied to detect serum YKL-40 and chemiluminescence method was applied to detect serum SCCag levels in patients with cervical cancer (n=53), cervical intraepithelial neoplasias (CIN, n=35) and healthy women (n=35). Results: The 90th percentile of YKL-40 values for normal control group was 93.33 ng/mL; The serum YKL-40 and SCCag levels in cervical cancer group were significantly higher than that in each of the two control groups; the serum SCCag level differed significantly between the two control groups; However, the serum YKL-40 level did not differ significantly between the two control groups. The serum SCCag level showed a significant correlation with FIGO stage, nodal status and tumer size while serum YKL-40 showed a significant correlation with FIGO stage, but did not have a significant correlation with nodal status and tumer size. With detection of serum YKL-40 and SCCag, the sensitivity was 79.20% and 77.38%, respectively; while with combined detection of serum YKL-40 and SCCag, the sensitivity could reach 94.34%. Conclusion: SermYKL-40 may be a new tumor marker in cervical cancer diagnosis, and combined detection of YKL-40 and SCCag can improve the sensitivity of early cervical cancer diagnosis, so it has important value in detection of malignant degree, evaluation for clinical stage and surgical treatment and evaluation curative effect of cervical cancer.
