WANG Liangrong,JIN Lida,LIN Lina, et al. The effect of diabetes on inflammatory response and pulmonary function in patients undergoing limb ischemia-reperfusion[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(3): 194-.
Abstract：Objective: To investigate the effect of type 2 diabetes on inflammatory response and pulmonary function in patients undergoing limb ischemia-reperfusion induced by tourniquet, and to study its relationships with blood glucose control level and disease duration. Methods: Eight-five patients scheduled for unilateral lower extremity surgery were enrolled and divided into Diabetes (n=55) and Control (n=30) Group, Diabetes Group was allocated into several sub-groups according to blood glucose control level and disease duration, respectively. The patients received epidural anesthesia and radial arteries catheterization, and the tourniquet duration lasted for 1-1.5 h. The arterial blood gases and serum Tumor Necrosis Factor-α (TNF-α) and interleukine-6 (IL-6) were measured immediately before tourniquet inflation, 2 h, 6 h and 24 h after tourniquet deflation. Results: Serum levels of TNF-α and IL-6 were significantly elevated at 2 h, 6 h and 24 h after tourniquet deflation, and the values of alveolar-arterial oxygen tension difference (PA-aDO2) and respiratory index (RI) were increased were increased at 2 h and 6 h after tourniquet deflation in both two groups (P<0.05). As compared to Control Group, the serum levels of TNF-α and IL-6 were higher, and PA-aDO2 and RI values were larger in Diabetes Group at 6h after tourniquet deflation (P<0.05), which were closely related to blood glucose control level and disease duration.
Conclusion: Type 2 diabetes aggravates the inflammatory mediators release and pulmonary gas exchange function, which relates to blood glucose control level and disease duration.
