Efficacy of dexmedetomidine on mechanical ventilation after uvulopalatopharyngoplasty
1.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Respiration, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
YANG Pei1,ZHOU Ying2,ZHANG Xuezheng1, et al. Efficacy of dexmedetomidine on mechanical ventilation after uvulopalatopharyngoplasty[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(2): 131-.
Abstract：Objective: To compare the effect of sedation between dexmedetomidine and midazolam for severe obstructive sleep apnea hypopnea syndrome (OSAHS) after uvulopalatopharyngoplasty (UPPP). Methods: Sixty-four ASA I~II patients of severe OSAHS scheduled for UPPP were randomly allocated into group D (dexmedetomidine, n=32) and group M (midazolam, n=32). The patients of the two groups were sedated with dexmedetomidine or midazolam respectively in the ICU after surgery and Ramsay scores of 3-4 were maintained. Sufentanil were added for analgesia. The supposed hypertension or tachycardia were treated with extra medication. The administration of sedative was stopped after 20 hours stay in ICU and the patients were sent back to ward when the Aldrete score reached 10. Results: The anticipated depth of sedation were acquired in 63 patients and there was a significant difference (P<0.05) demonstrated by 24 patients in group D while 8 patients in group M received no extra medication for hypertension or tachycardia. The level of stress hormone, the mean arterial pressure and heart rate were significantly lower in group D than group M at 2 h (T1), 10 h (T2), 20 h (T3) after entering ICU and before extubation (T4) respectively. The time intervals between medication suspend and departure from ICU were significantly shorter while the degree of satisfaction for the process of sedation were higher in group D than that in group M. Conclusion: Dexmedetomidine has better features of sedation than midazolam for the patients of severe OSAHS with mechanical ventilation after UPPP in ICU.
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