Predictive value of interleukin-6 and procalcitonin for lower extremity amputation in patients with diabetic foot ulcers
1.Department of Endocrinology, Lishui Central Hospital, Lishui Hospital of Zhejiang University, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000; 2.College of Medicine and Health, Lishui University, Lishui, 323000
HE Yinhui1,XU Haiyan1,YANG Ruhui2, et al. Predictive value of interleukin-6 and procalcitonin for lower extremity amputation in patients with diabetic foot ulcers[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(2): 112-.
Abstract：Objective: To determine clinical and laboratory factors that predict amputation surgery and to evaluate the predictive value of interleukin-6 (IL-6), and procalcitonin (PCT) in patients with diabetic foot ulcers (DFUs). Methods: Forty-five DFUs patients admitted to our hospital were consecutively enrolled. The patients’ demographics and wound characteristics were noted. IL-6 and PCT were measured at admission. Results: Twelve of the 45 patients (26.7%) eventually underwent lower extremity amputation. Compared to the non-amputation group, a previous history of amputation (P=0.003), the presence of gangrene (P=0.019), the Wagner grade (P=0.002), the lower extremity neuropathy (P=0.011), the IL-6 concentration (P=0.012), the white blood cell count (WBC) (P=0.033), and the erythrocyte sedimentation rate (ESR) (P=0.040) were significantly high in the amputation group. However, the PCT concentration was not significantly different. Conclusion: PCT failed to predict patients who will eventually require amputation and IL-6 may have predictive value for lower extremity amputation in patients with DFUs. Further studies are needed to confirm its predictive value in patients with DFUs.
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