血清基质金属蛋白酶及其抑制剂与肥胖儿童左心室功能的关系

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摘要目的：探讨血清基质金属蛋白酶（MMPs）及其抑制剂（TIMPs）与肥胖儿童左心室功能的关系。方法：对30例单纯肥胖儿童（肥胖组）和30例正常儿童（对照组）分别进行血脂、收缩压、舒张压、血糖水平的检查；心脏彩色多谱勒超声测定心功能；血清MMPs与TIMPs的水平采用酶联免疫吸附试验（ELISA）法检测。结果：①肥胖组血脂、收缩压、舒张压、血糖水平显著高于对照组（P＜0.05）；②肥胖组血清MMPs水平明显高于对照组，而TIMPs水平低于对照组，差异均有统计学意义（P＜0.05）；③肥胖组左心室功能存在改变，左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室后壁厚度（LVPWT）、室间隔厚度（IVST）明显高于对照组（P＜0.05）；④肥胖组左室结构功能指标与MMP-8、MMP-9水平呈正相关。结论：肥胖儿童血清中存在MMPs及其抑制剂TIMPs水平的改变，血清MMPs水平与左室结构功能指标呈正相关，提示儿童肥胖增加了心血管疾病的危险因素，血清MMPs可能参与了肥胖儿童左心室结构的重塑，从而引起了左心室功能的改变。

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	蓝俊伟
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	刘晟
	潜丽俊

关键词 ：肥胖儿童, 血清基质金属蛋白酶, 血清基质金属蛋白酶抑制剂, 心脏超声

Abstract：Objective: Through the study of serum levels of matrix metalloproteinases (MMPs) and its inhibitors (TIMPs), to investigate obesity children at high risk of developing cardiovascular disease impaction on cardiac function. Methods: Blood lipid, systolic pressure, diastolic pressure, blood sugar levels were examined in 30 simple obesity children and 30 normal children; echocardiography (ECHO) test cardiac function; MMPs and TIMPs using enzyme-linked immunosorbent assay (ELISA) detection. Results: ①Blood lipids, systolic pressure, diastolic pressure, blood sugar level in obese children were significantly higher than that in control group (P<0.05); ②Serum levels of MMPs in obese children were significantly higher than that in the control group (P<0.05), while TIMPs levels were lower than the normal control group (P<0.05); ③The left ventricular function changed in obese children, LVEDD, LVESD, LVPWT, IVST levels were significantly higher than that in control group (P<0.05); ④The left ventricular function indicators of obese children were positively correlated with children, the levels of MMPs were positively correlated with the left ventricular function index MMP-8, MMP-9 levels, prompting obesity increases the risk factor for cardiovascular disease, MMPs might participate in the structure remodeling of the left ventricle in obese children, thus caused the change of left ventricular function.correlated. Conclusion: Serum levels of MMPs and TIMPs had changed in school-age obesity children, the levels of MMPs were positively correlated with the left ventricular function index, suggesting obesity increases the risk factor for cardiovascular disease, MMPs may participate in the structure remodeling of the left ventricle in obese children, thus caused the change of left ventricular function.

Key words： obese children serum levels of matrix metalloproteinases serum levels of matrix metallopro-teinases inhibitor echocardiography.

收稿日期: 2014-05-04

基金资助:丽水市科技局科研基金资助项目（2009XK02）。

通讯作者: 潜丽俊，主任医师，Email：toofe2007@163.com。

作者简介: 蓝俊伟（1985-），男，浙江云和人，住院医师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2015/V45/I1/31

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