LIN Haixia,SU Zhen,HE Limei, et al. Clinical characteristics about immunosuppressant related pneumocystis carinii pneumonia in kidney disease[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(7): 524-.
Abstract：Objective: To analyze etiology and clinical characteristics of pneumocystis carinii pneumonia in kidney disease patients who accepted immunosuppressive therapy. Methods: Retrospective analyse clinical datas and immunosuppressive schemes of 49 cases kidney disease patients, accompanied with lung infection during June, 2006 to August, 2013 from the First Affiliated Hospital of Wenzhou Medical University. Results: Kidney transplant patients were 20 cases, non-kidney transplant patients were 29 cases. Membranous nephropathy patients were 8 cases, vasculitis associated nephropathy patients were 3 cases, IgA nephropathy patients were 4 cases, lupus nephritis patients were 7 cases, purpura nephritis was 1 case, the other chronic glomerulonephritis patients were 26 cases. Interstitial pneumonia was the main clinical feature in patients, who mainly represent with breathing trouble, cough and fever. 12 cases of pneumocystis carinii pneumonia (PCP), including 9 cases of kidney transplant patients, 3 cases of non-kidney transplant patients. Conclusion: The high incidence of lung infection is observed in kidney disease patients who accepted immunosuppressive therapy in the first year (53.0%), especially in patients of renal transplantation in 6 months. The patients of PCP have no specific clinical manifestations, and are prone to respiratory failure, and hypoalbuminemia is one of the independent risk factors for PCP, we should pay attention to PCP, give a sufficient amount of sulfamethoxazole, use plasma and albumin if necessary, and adjust the dosage of immunosuppressant in time.
