Dexmedetomidine enhances the efficacy of local anesthetics on sciatic nerve block
1.Department of Anesthesiology, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital Wenzhou, 325099; 2.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
HU Xiawei1,ZHOU Riyong2,WANG Quanguang2, et al. Dexmedetomidine enhances the efficacy of local anesthetics on sciatic nerve block[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(7): 508-.
Abstract：Objective: A randomized and double-blinded observation anesthesia efficacy of dexmedetomidine on local anesthetics for popliteal sciatic nerve block. Methods: Sixty patients who undergone unilateral great saphenouse vein surgery were randomly divided into two groups: Group DL and Group SL (n=30). Ultrasound-guided sciatic nerve block proximal to the neural bifurcation at the popliteal fossa combined with femoral and obturator nerve block were performed in all patients. The sciatic nerve was blocked with 2% lidocaine 9.5 mL and 0.75% ropivacaine 10 mL combined with 0.5 mL (50 μg) dexmedetomidine or 0.5 mL saline in Group DL and Group SL respectively, totally 20 mL. The sensory onset time of lateral sural cutaneous nerve (CN), sural nerve (SN), superficial peroneal nerve (SPN), profundum peroneal nerve (PPN), lateral plantar nerve (LPN) and medial plantar nerve (MPN) were recorded; the motor onset time of tibial nerve and common peroneal nerve were recorded; furthermore,the duration of sensory and motor block were recorded. Results: The sensory onset time of SN, SPN, LPN and MPN in Group DL were significantly faster than those in Group SL (P<0.05), whereas the sensory time of CN and SPN were not different between the two groups (P>0.05); the motor onset time of tibial nerve and common peroneal nerve in Group DL were significantly faster than those in Group SL (P<0.05); the duration of sensory and motor block were significantly faster in Group DL than those in Group SL (P<0.05). Conclusion: Dexmedetomidine enhances the anesthesia efficacy of local anesthetics on sciatic nerve block.
