JIAO Lizhuo,CHEN Hanbin,ZHAO Lingling, et al. Expressions and significance of p40, TTF-1, p63 and CK5/6 in lung adenocarcinoma and squamous carcinoma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(7): 489-.
Abstract：Objective: To explore the expression and differential significance of p40, TTF-1, p63 and CK5/6 in adenocarcinama and squamous carcinoma of lung. Methods: Using the technology of tissue microarray and immunohistochemical method, the expression of p40, TTF-1, p63 and CK5/6 was detect in 108 cases specimens of lung adenocarcinoma and 66 cases specimens of lung squamous carcinoma and the difference and clinical pathological significance were analyzed. Results: ①The positive expression rates of p40, p63, CK5/6, TTF-1 in lung squamous cell carcinoma were 93.9% (62/66), 86.4% (57/66), 89.4% (59/66) and 6.1% (4/62), respectively. ②The positive expression rates of p40, p63, CK5/6, TTF-1 in lung adenocarcinoma were 3.7 (4/108), 22.2% (24/108), 24.1% (26/108) and 95.4% (103/108). ③The specificity of p40, p63, CK5/6 for lung squamous carcinoma was 96.3%, 77.8% and 75.9%, the specificity of p40 was higher than that of p63 and CK5/6 (P<0.05). ④p40, p63 and TTF-1 had relevant with gender, pathological type, tumor size, history of smoking (P< 0.05), and had no relevant with age, the degree of differentiation, lymph node metastasis and TNM stages (P> 0.05). ⑤The expression rate of p40 (89.3%) was higher than that of p63 (78.6%) and CK5/6 (82.1%) in poorly differentiated lung squamous carcinoma. Conclusion: p40, p63, CK5/6 and TTF-1 have a important value in the diagnosis and identify of lung cancer. p40 is obviously better than p63 and CK5/6 in the identification of lung squamous carcinomas, and has higher expression rate in poorly differentiated squamous carcinoma of lung. Gender, pathological type, tumor size, history of smoking are relevant with the expression of p40, p63, TTF-1 and CK5/6.
