The prenatal diagnosis and genetic background of fetal growth restriction
CHEN Yangping1, 2, HUANG Hailong2.
1.Wenzhou Central Hospital, Department of Obstetrics & Gynecology , Wenzhou 325000, China;2.Medical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China
CHEN Yangping,HUANG Hailong. The prenatal diagnosis and genetic background of fetal growth restriction[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(8): 672-677.
Abstract：Fetal growth restriction (FGR) is one of the most formidable challenges in prenatal period,which could cause not only fetal death in the third trimester in utero, but also adult metabolic syndrome such as metabolic diseases, diabetes and hypertension. There is no obviously effective treatment in utero. Its etiology is complex, with fetal genetics as one of the important reasons. Prenatal identification of the genetic etiology of FGR is crucial to the prognosis of FGR. Chromosome microarray analysis can detect about an extra 10% of copy number variation in addition to chromosome karyotype analysis, but there are many reasons unknown yet.Postnatal application of whole exome sequencing can detect additional monogenic diseases. With the development of whole exome sequencing technology followed with reduced cost, it is expected to become the first-tier prenatal detection method for FGR.
