Association between ceramide and risk of new-onset atrial fibrillation in acute myocardial infarction
GUAN Fanlu1, 2, JIANG Wenbing1, 3.
1.The Dingli Clinical College of Wenzhou Medical University, Wenzhou 325000, China; 2.Department of Cardiovascular Medicine, Wenzhou People’s Hospital, Wenzhou 325000, China;3.Department of Cardiovascular Medicine, Wenzhou Hospital of Integrated Chinese and Western Medicine,Wenzhou 325000, China
GUAN Fanlu,JIANG Wenbing. Association between ceramide and risk of new-onset atrial fibrillation in acute myocardial infarction[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(8): 657-663.
Abstract：Objective: To analyze the clinical features of new-onset atrial fibrillation in patients with acute myocardial infarction, and to explore the association between ceramides and the risk of new-onset atrial fibrillation.Methods: From January 2020 to March 2024, a total of 815 patients with acute myocardial infarction in Wenzhou people’s hospital were enrolled. Among them, 85 patients developed new-onset atrial fibrillation within 24 hours of admission. Demographics, comorbidities, laboratory tests, and ceramide (C16, C24, C24:1) were collected at admission and compared between the two groups (atrial fibrillation vs non-atrial fibrillation). Multivariate Logistic regression was used to adjust for different variables, and then the association between ceramide and the risk of new-onset atrial fibrillation in patients with myocardial infarction and the potential mechanism were analyzed.Results: Compared with non-atrial fibrillation, the patients with new-onset atrial fibrillation were mainly male,significantly older, and had more comorbidities. After adjustment for baseline characteristics, ceramides were associated with the risk of atrial fibrillation in patients with MI (C16: OR=1.99, 95%CI=1.15-3.46, P=0.014;C24: OR=0.87, 95%CI=0.78-0.97, P=0.013; C24:1: OR=1.33, 95%CI=1.05-1.69, P=0.016), the association was attenuated after the adjustment of CRP and NT-proBNP. Conclusion: Ceramides were associated with newonset atrial fibrillation in patients with myocardial infarction, with increased C16 and C24:1 associated with an increased risk of atrial fibrillation, while increased C24 was associated with a reduced risk of atrial fibrillation.
