Meta-analysis of autologous soft tissue replacement materials in the treatment of natural tooth gingival recession
CAI Zhibin1, HE Kuifang1, DENG Hui2.
1.Department of Endodontics, Hospital of Stomatology,Wenzhou Medical University, Wenzhou 325027, China; 2.Department of Periodontology, Hospital of Stomatology,Wenzhou Medical University, Wenzhou 325027, China
CAI Zhibin,HE Kuifang,DENG Hui. Meta-analysis of autologous soft tissue replacement materials in the treatment of natural tooth gingival recession[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(6): 501-507,513.
Abstract：Objective: To systematically evaluate and compare from the perspective of clinical indicators the efficacy of autologous soft tissue replacement materials and connective tissue grafts combined with coronal reduction flap technology in the treatment of natural tooth gingival recession. Methods: Computer retrieval of randomized controlled trials using autologous soft tissue replacement materials or connective tissue grafts (CTGs) for the treatment of gingival recession from databases such as PubMed, EMBASE, Web of Science, VIP,Wanfang, and CNKI, with a search period from January 2013 to December 2023. Results: Totally 14 randomized controlled studies were included, with 1 117 sites of gingival recession. Meta-analysis showed that at 6 months after surgery, CTG was more effective in reducing gingival recession compared with xenogeneic collagen matrix (XCM), but was not significantly different from platelet rich fibrin (PRF) or decellularized dermal matrix (ADM).Compared with PRF, ADM, and XCM, CTG had a more significant increase in keratinized gingival width.There was no statistical difference in the root coverage index; PRF and XCM significantly reduced postoperative pain in patients. Conclusion: Research has shown that there is no significant difference in the effectiveness of autologous soft tissue replacement materials compared with CTG in treating gingival recession, but the former can relieve postoperative pain in patients.
