Analysis on indexes of lipid metabolism and status indicators before blood clots in patients with obstructive sleep apnea hypoventilation syndrome accompanied chronic obstructive pulmonary disease
Department of Respiratory Medicine, the People’s Hospital of Wenzhou, Wenzhou, 325000
YE Huan,XU Bin,SHI Xiaohong, et al. Analysis on indexes of lipid metabolism and status indicators before blood clots in patients with obstructive sleep apnea hypoventilation syndrome accompanied chronic obstructive pulmonary disease[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(7): 503-.
Abstract： Objective: To observe the changes of indexes of lipid metabolism and status indicators before blood clots in patients with OSAHS (obstructive sleep apnea hypoventilation syndrome) accompanied COPD (chronic obstructive pulmonary disease), and whether lipid metabolism disorder and hypercoagulable state exist in them is discussed. Methods: Patients with OSAHS accompanied COPD were brought into OS (overlap syndrome) group. There were 30 cases in OS group, 41 cases in OSAHS group, 48 cases in COPD group and 45 cases in control group separately. Pulmonary function test and blood specimen detection were carried in all individuals. Blood specimen detection included triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), non-high density lipoprotein-cholesterol (non-HDL-C), lipoprotein (α) (Lpα), apolipoprotein A1 (apoA1), apolipoprotein B (apoB), fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), plasma D-dimmer (D-Dimmer) and homocysteine (Hcy). Statistic analysis was carried with SPSS l8.0. Results: apoA1 and HDL-C in OS group and 0SAHS group were less than those in control group and COPD group significantly (P<0.05). apoA1 and HDL-C in OS group were less than those in 0SAHS group significantly (P<0.05). LPα, apoB, TG, TC, LDL-C and N-HDL-C in OS group and 0SAHS group were more than those in control group and COPD group significantly (P<0.05). LPα, apoB, TG, TC, LDL-C and non-HDL-C of OS group were more than those in 0SAHS group significantly (P<0.05). There was no significant difference between control group and COPD group in apoA1, HDL-C, LPα, apoB, TG, TC, LDL-C and non-HDL-C (P>0.05). PT, APTT and TT in OS group, 0SAHS group and COPD group were less than those in control group significantly (P<0.05). PT, APTT and TT in 0S group were less than those in 0SAHS group and COPD group significantly (P<0.05). FIB, D-Dimmer and Hcy in OS group, 0SAHS group and COPD group were more than those in control group significantly (P<0.05). FIB, D-Dimmer and Hcy in OS group were more than those in 0SAHS group and COPD group significantly (P<0.05). There was no significant difference between 0SAHS group and COPD group in PT, APTT, TT, FIB, D-Dimmer, Hcy (P>0.05). Conclusion: OSAHS and OS can induce plasma lipid metabolism disorder, and hypercoagulable state exist in patients with COPD or 0SAHS or OS, and patients with OS is obvious relatively.
