Effect of transcutaneous electrical acupoint stimulation on immunity and clinical prognosis of patients with lumbar disc herniation
QIAN Xuwen1, LI Guoyan2, LIU Guokai2, TANG Wenqian2, LI Chuntian3.
1. Department of Anesthesiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;2.Department of Anesthesiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China; 3.Department of Acupuncture, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
QIAN Xuwen,LI Guoyan,LIU Guokai, et al. Effect of transcutaneous electrical acupoint stimulation on immunity and clinical prognosis of patients with lumbar disc herniation[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(6): 446-451.
Abstract：Objective: To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on the immune balance, postoperative infection and clinical prognosis in patients with lumbar disc herniation undergoing open spine surgery. Methods: A total of 112 patients who met the inclusion criteria were selected as the research subjects, who were divided as a simple general anesthesia group (control group) and an electrical acupoint stimulation combined with general anesthesia group (experimental group) according to the computergenerated random table, with 56 cases in each. The serum indexes (IL-2, TNF-α, IFN-γ, IL-4, IL-6, IL-10, TGF-β,IL-17), BIS value and postoperative complications (incision infection, nausea and vomiting) were observed before anesthesia (T0), tracheal intubation (T1), skin incision (T2), insertion of the first pedicle screw (T3), the end of operation (T4), the first day after operation (T5) and the second day after operation (T6) to explore the effect of TEAS on the immune balance and clinical prognosis in patients undergoing open spine surgery. Results:Compared with T0, IL-17 levels in the control group increased more at T4 time point (P<0.05); TGF-β level in both groups increased at T2, T4, T5, T6 time points (P<0.05). Compared with the control group, IL-2 level in the experimental group was significantly lower at T4 and T6 time points (P<0.01); the level of IL-4 in the experimental group was significantly higher at T3 and T4 time points (P<0.05); the level of IFN-γ in the experimental group was significantly lower at T1 and T5 time points (P<0.05); the level of IL-17 in the experimental group was significantly lower at T4 (P<0.05); TGF-β levels were significantly increased at T3 (P<0.01). The incision infection rate of the experimental group (1, 1.7%) was lower than that of the control group (5, 8.9%), with statistical difference (P<0.05). The incidence of postoperative nausea and vomiting in the experimental group (8, 14%) was lower than that in the control group (24, 43%), with sighificant difference (P<0.05); The BIS value of the experimental group was higher than that of the control group at the end of operation, showing statistical difference between the two groups (P<0.05). Conclusion: The application of TEAS during peri-operation can improve the patients’ immune balance, reduce the inflammatory reaction, increase the anti-inflammatory response, thus reducing the occurrence of postoperative infection. Meanwhile, it can shorten the recovery time and significantly reduce postoperative complications such as nausea and vomiting.
