Effect of bovine basic fibroblast growth factor combined with chlortetracycline hydrochloride eye ointment on wound healing of oral-mucosal pressure injury after orthognathic surgery
XU Ping1, XIAO Jin1, WANG Huimin1, ZHANG Chenxin1, MEI He2, SONG Li3, GUO Junyi1.
1.Department of Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325000, China; 2.College of Public Health,Wenzhou Medical University, Wenzhou 325035, China; 3.Sanjiang Street Community Health Service Center of Wucheng District, Jinhua 321000, China
XU Ping,XIAO Jin,WANG Huimin, et al. Effect of bovine basic fibroblast growth factor combined with chlortetracycline hydrochloride eye ointment on wound healing of oral-mucosal pressure injury after orthognathic surgery[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(5): 390-395..
Abstract：Objective: To explore the clinical effect of bovine basic fibroblast growth factor for external use
combined with chlortetracycline hydrochloride eye ointment on wound healing of oral-mucosal pressure injury after orthognathic surgery. Methods: Patients with oral-mucosal pressure injury after orthognathic surgery in the Affiliated Hospital of Stomatology, Wenzhou Medical University from June 2018 to September 2023 were selected as subjects, who were divided into three groups according to the medication methods as the group of chlortetracycline hydrochloride eye ointment, the group of bovine basic fibroblast growth factor for external use and the group of bovine basic fibroblast growth factor for external use combined with chlortetracycline hydrochloride eye ointment (denoted as combination group), with 30 cases in each group. The pain degree,mouth opening, wound healing time and satisfaction degree were compared between the three groups. Results:After 5 days of medication, the visual analogue scale (VAS) score of the three groups were all significantly decreased (P<0.05) and the mouth opening of the three group were distinctly enlarged (P<0.05), compared with before medication. After 5 days of medication, the differences of VAS score and the mouth opening among the three group were statistically significant (H=13.921, P=0.001; F=8.569, P<0.001). The combination group had the lowest VAS score and the biggest mouth opening compared with the other two groups (P<0.05). There was statistical difference in the values of VAS score and the mouth opening before and after medication among the three group (H=18.292, P<0.001; F=6.720, P=0.002), and the difference value of the combination group was the biggest. The difference in the wound healing time and satisfaction degree for the three group were statistically significant (F=9.510, P<0.001; χ2=8.940, P=0.011), in which the combination group had the shortest healing time and greatest satisfaction degree (P<0.05). Conclusion: The combination of bovine basic fibroblast growth factor for external use with chlortetracycline hydrochloride eye ointment can improve patients’ satisfaction degree in that it promotes the wound healing of oral-mucosal pressure injury after orthognathic surgery, reduces postoperative pain and enlarges the mouth opening while shortens the wound healing time.
