1.Department of Clinical Laboratory, the Second Affiliated Hospital & Yuying Children’s Hospital of
Wenzhou Medical University, Wenzhou 325027, China; 2.School of Laboratory Medicine, Hangzhou Medical
College, Hangzhou 310059, China
HUANG Yifan,QI Xinyi,LIU Xiujing, et al. Pathogen spectrum of acute respiratory tract infections in hospitalized children of Wenzhou city from 2021 to 2022: A single-center analysis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(4): 279-286.
Abstract：Objective: To analyze the changes of common respiratory pathogens in hospitalized children with respiratory tract infections (ARIs) in Wenzhou between 2021 and 2022, and provide reference for accurate
diagnosis, treatment, prevention and control of ARIs. Methods: The results of 13 respiratory pathogens in hospitalized children with ARIs admitted to the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from January 2021 to December 2022 were retrospectively analyzed. The pathogen spectrum characteristics of ARIs patients in 2021 and 2022 as well as the differences in genders, ages, seasons, and pathogen infection patterns were compared and analyzed. Results: The total positive rate of pathogens in 2021 and 2022 was 70.74% (3 477/4 915) and 70.74% (6 099/8 622), respectively. The top five main pathogens have evolved from human rhinovirus (HRV), human respiratory syncytial virus (HRSV), human parainfluenza virus (HPIV), human adenovirus (HADV) and human metapneumovirus (HMPV) in 2021 to HRV, mycoplasma pneumoniae (Mp), HRSV, HADV, and HMPV. Compared with 2021, the positive rates of MP, HADV, and HMPV in 2022 were significantly higher than in 2021, while HRV, HRSV, and HPIV were significantly lower than in 2021(all P<0.01). In 2022, the overall positive rate of respiratory pathogens in boys was slightly higher than that in girls, with the highest detection in the 2-<4-year-old group and in summer (all P<0.01). Compared with 2021, there was an outbreak trend of Mp infection in 2022, which was most obvious in summer, especially in the 7-14-year age group. The onset age of different major pathogens tends to be younger or older, and the high incidence season is, to some extent, advanced or prolonged in time or exchanged in season. In 2022, single infection increased significantly, while multiple infection decreased significantly, and multiple infection was mainly from HRV+Mp. Conclusion: The pathogen spectrum of hospitalized children with ARIs in Wenzhou in 2022 showed great differences from that in 2021. Low- aged children are still the focus population of prevention and control. The increasing infection rates of Mp, HADV and HMPV and the outbreak of H3N2 influenza A virus should be of great concern. It is recommended that the etiological surveillance of ARIs should be continuously strengthened.
