LU Yuliang,WEI Fanping,CHEN Zhenfeng. Influence of telmisartan on the impaired glucose regulation in patients with hypertention[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(5): 373-.
Abstract：Objective: To explore the influence of telmisartan on the impaired glucose regulation (IGR) of patients with hypertention. Methods: Ninety patients with IGR and hypertension who were selected in our hospital were randomly divided into two groups. The patients in study group (45 cases) were treated by taking telmisartan 40~80 mg per day for 12 weeks and the patients in control group (45 cases) were required to take irbesartan 75~150 mg per day for 12 weeks. Their blood pressure (BP) and the insulin sensitivity including fasting plasma glucose (FPG), 2 hours postprandial glucose (2hPG), glycosylated hemoglobin, fasting insulin (FINS) and insulin resistance index (IRI) were observed and analysed after 12 weeks. Results: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased significantly in both groups after treatment (P<0.05). Compared with the control group, FBG, 2hPG, HbA1c, FINS and IRI in the study group decreased after telmisartan treatment (P<0.05). Conclusion: Telmisartan can effectively improve glucose metabolism in the patients with IGR and hypertension.
